Luk khrueng (Thai: ลูกครึ่ง, literally “half-child”) is a colloquial Thai term referring to a person whose parents are of different nationalities. In a narrow sense, luk khrueng means people of mixed Thai and foreign origin.
If you marry a Thai and have children, your kids will be referred in Thailand as Luk Khrueng, which is a mixed kid (parents from Thai and a different nationality.)
Many of the Miss Universe and famous actresses are Luk Khrueng kids.
The mixture results is kids that have very beautiful features and are admired by all Thai’s.
Your children, whether in Isaan or elsewhere, will fit in the same as all Thai children.
There is nothing to worry about.
Luk Khreung have the benefit of learning 2 languages which is beneficial when they get older.